402-52-8, These common heterocyclic compound, 402-52-8, name is 1-Methoxy-4-(trifluoromethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 249A 1-(2-methoxy-5-(trifluoromethyl)phenyl)ethan-1-one A 250 mL 3-neck round bottom flask equipped with a thermometer and an addition funnel was charged with trifluoromethanesulfonic acid (29.6 mL, 333 mmol) and then treated dropwise (?6 drops/minute) under N2 over 3 hours with a mixture of 4-(trifluoromethyl)anisole (11.74 g, 66.6 mmol) and acetic anhydride (12.57 mL, 133 mmol) keeping the internal temperature at or below 30 C. The resulting mixture was stirred at room temperature for 3 hours and then poured carefully into 150 mL of ice water, adding more ice during the addition to prevent the mixture from warming. The mixture was extracted with methyl tert-butyl ether (twice, 150 mL and 50 mL). The combined methyl tert-butyl ether layers were washed with saturated aqueous NaHCO3 solution 4 times (100 mL, 100 mL, 50 mL and 50 mL). The methyl tert-butyl ether layer was washed with brine, dried (MgSO4), filtered, concentrated, and chromatographed on silica gel, eluting with a gradient of 5% to 10% ethyl acetate in heptane to provide the title compound. 1H NMR (400 MHz, CDCl3) delta ppm 8.00 (dd, J=0.8, 2.5 Hz, 1H), 7.70 (ddd, J=0.8, 2.5, 8.8 Hz, 1H), 7.05 (d, J=8.7 Hz, 1H), 3.97 (s, 3H), 2.62 (s, 3H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 402-52-8.
Reference:
Patent; AbbVie S.a.r.l.; Galapagos NV; Altenbach, Robert J.; Bogdan, Andrew; Desroy, Nicolas; Gfesser, Gregory A.; Greszler, Stephen N.; Koenig, John R.; Kym, Philip R.; Liu, Bo; Scanio, Marc J.; Searle, Xenia; Wang, Xueqing; Yeung, Ming C.; Zhao, Gang; (247 pag.)US2018/99932; (2018); A1;,
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