20265-97-8, The chemical industry reduces the impact on the environment during synthesis 20265-97-8, name is 4-Methoxyaniline hydrochloride, I believe this compound will play a more active role in future production and life.
p-Anisidine hydrochloride (23.14 g, 132.5 mmol) was dissolved in ethanol (400 mL) and TRIFLUOROACETALDEHYDE ethyl hemiacetal (20 mL, 172.3 mmol) was added and refluxed overnight. The reaction was concentrated, and the crude compound was redissolved in N, N-dimethylformamide (150 mL) and cooled to 0C. N-BROMOSUCCINIMIDE (23.59 g, 132.5 mmol) was added to the solution over five minutes. The reaction was warmed to rt and stirred overnight. The reaction was quenched with water (1000 mL) and ethyl acetate (5000 mL), extracted with ethyl ACETATE (3X500 ML), WASHED WITH brine (1×500 ML) 7 DRIED OVER NA2804, concentrated, and purified by flash chromatography using 0-10% ethyl acetate/hexanes as eluent afforded 18. 8 g (48%) of the hydrazone intermediate
The chemical industry reduces the impact on the environment during synthesis 4-Methoxyaniline hydrochloride. I believe this compound will play a more active role in future production and life.
Reference:
Patent; BRYSTOL-MYERS SQUIBB COMPANY; WO2004/83177; (2004); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem