A common heterocyclic compound, 437-83-2, name is 3-Fluoro-2-methoxyaniline, molecular formula is C7H8FNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 437-83-2.
Step D: 1-bromo-3-fluoro-2-methoxybenzene: NaN02 (12.0 g, 173 mmol, in 40 mL of water)solution was added dropwise to the mixture of 3-fluoro-2-methoxyaniline (20.0 g, 158 mmol) in 200 mL of hydrobromic acid ( 4 7 %) and 100 mL of water at -5 ~ 0 C and stirred for 1 hour.This solution was then added slowly to the suspension ofCuBr (45.2 g, 315 mmol) in 50 mL ofhydrobromic acid (47 %) at 0 C. The resulting mixture was stirred at 0 C for 1 hour thenwarmed to 50 C and stirred for 1 hour. The reaction mixture was poured into ice water and extracted with ether (2 X 500 mL). The combined organic layer was washed with brine, driedover anhydrous Na2S04 and concentrated to give 1-bromo-3-fluoro-2-methoxybenzene.
The synthetic route of 3-Fluoro-2-methoxyaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; WO2013/28474; (2013); A1;,
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