As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 101-55-3 name is 1-Bromo-4-phenoxybenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 101-55-3
A mixture of compound (III) (Pgi = Pg2 = Boc) (837 mg, 2.00 mmol), PdCl2 (35 mg, 0.20 mmol), 4,4?-di(tert-butyl)-2,2?-bipyridine (54 mg, 0.20 minol), Cs2CO3 (716 mg, 2.20 rnmol), 1-bromo-4-phenoxybenzene (548 mg, 2.20 mmol) and diglyme (10 ml) was heated in a sealed tube under argon atmosphere at 110C for 20 h with intensive stirring. After completion of the reaction the tube was cooled to room temperature, carefully opened, and the reaction mass was poured into EtOAc (40 ml). After intensive stirring for 5 mm the obtained suspension was filtered through celite un evaporated in vacuum. The product was purified by column chromatography (eluent EtOAc-hexane 1:4, Rf 0.3). Yield 727 mg (62%), white amorphous powder.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-phenoxybenzene, and friends who are interested can also refer to it.
Reference:
Patent; LATVIAN INSTITUTE OF ORGANIC SYNTHESIS; LEBEDEVS, Antons; PONOMARJOVS, Jurijs; VARACEVA, Larisa; CERNAKS, Dmitrijs; CERNOBROVIJS, Aleksandrs; LAVRINOVICS, Edvards; (15 pag.)WO2017/39425; (2017); A1;,
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