2752-17-2, These common heterocyclic compound, 2752-17-2, name is 2,2′-Oxydiethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Diester1 (1mmol) and the appropriate diamine2-6 (1mmol) were dissolved in dry methanol (50mL) and sodium methoxide (2mmol) was added. A mixture was stirring for 72hat room temperature. After completion of the reaction (controlled by TLC), the solvent was evaporated under reduced pressure and the oily residue was purified by column chromatography (1-5% MeOH in CH2Cl2). All the macrocyclic products obtained in this way are colourless solids, stable to air. 4.2.1 Macrocycle (R)-714b (0010) Yield: 60% (282mg); [alpha]D25 +86.4 (c=0.1, CH2Cl2); Mp. 245-246C; 1H NMR (400MHz, CDCl3):delta=8.02 (d, J=9.0Hz, 2H), 7.90 (d, J=8.2Hz, 2H), 7.45-7.21 (m, 6H), 7.07 (d, J=8.5Hz, 2H), 6.41 (br s, 2H), 4.60 (d, J=15.6Hz, 2H), 4.36 (d, J=15.6Hz, 2H), 3.71-3.56 (m, 2H), 3.51-3.39 (m, 2H), 3.38-3.27 (m, 2H), 2.97-2.86 (m, 2H); 13C NMR (100MHz, CDCl3):delta=168.5, 152.7, 133.6, 130.2, 129.8, 128.1, 127.2, 125.0, 124.6, 119.6, 114.1, 68.9, 68.7, 38.5; IR (film) 3423, 3294, 3056, 2914, 2866, 1674, 1533, 1507, 1273, 1213, 1094, 808, 735cm-1.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2752-17-2.
Reference:
Article; Pikus, Grzegorz; Jurczak, Janusz; Tetrahedron; vol. 72; 16; (2016); p. 1928 – 1932;,
Ether – Wikipedia,
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