New downstream synthetic route of 1535-73-5

The chemical industry reduces the impact on the environment during synthesis 1535-73-5. I believe this compound will play a more active role in future production and life.

The chemical industry reduces the impact on the environment during synthesis 1535-73-5, name is 3-Trifluoromethoxyaniline, I believe this compound will play a more active role in future production and life. 1535-73-5

Example 61 : 6-(6-Amino-pyrimidin-4-ylsulfanyl)-naphthalene-1-carboxylic acid (3- trifluoromethoxy-phenvP-amide; To 95 mg (0.32 mMol) 6-(amino-pyrimidin-4-ylsulfanyl)-naphthalene-1-carboxylic acid, 85 mg(0.48 mMol) 3-trifluoromethoxy-aniline, 446 mul (3.2 mMol) Et3N and 4 mg (0.03 mMol) DMAP EPO in 3 ml DMF, 0.37 ml (0.63 mMol) propylphosphonic anhydride are added. After 3 h at rt, the reaction mixture is worked up as described for Ex. 58, yielding the title compound: m.p.: 197- 199 ¡ãC; MS: [M+1]+ = 457.

The chemical industry reduces the impact on the environment during synthesis 1535-73-5. I believe this compound will play a more active role in future production and life.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2006/59234; (2006); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem