The important role of 366-99-4

Some common heterocyclic compound, 366-99-4, name is 3-Fluoro-4-methoxyaniline, molecular formula is C7H8FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 366-99-4

To 124 (1.09 g, 3.5 mmol) dissolved in acetone (25 mL) was added 3-fluoro- p-anisidine (0.54 g, 3.5 mmol) in acetone (5 mL) followed by addition of 2.5 N NaOH (1.4 mL, 3.5 mmol) and water (3.5mL). The reaction mixture was stirred and heated at reflux for 3 hours. The reaction mixture was extracted three times using dichloromethane ; the combined organic layers were washed with brine and dried over potassium carbonate. The sample was filtered, concentrated in vacuo, and the resulting solid was dried overnight under vacuum to yield white solid (E15) (1.332 g,97percent) ; mp194 C ; HPLC: Inertsil ODS 3V C18,40 : 30: 30 v: v: v[KH2P04(0. 01 M, pH 3.2) : CH30H: CH3CN], 264nm,Rt 33.2 min, 97.6percent purity; MS (TOF ES+)mlz 396 (35.0) ; 394 (M+H, 100).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 366-99-4, its application will become more common.

Reference:
Patent; REDDY US THERAPEUTICS, INC.; WO2004/26844; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem