398-62-9, name is 4-Fluoro-1,2-dimethoxybenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 398-62-9
EXAMPLE 138 6-Bromo-1-(2-fluoro-4,5-dimethoxyphenyl)-1-hexanone A solution of 5.3 g (0.034 mol) of 1,2-dimethoxy-4-fluorobenzene in 25 mL of methylene chloride was added to a solution of 5.4 g (0.041 mol) of aluminum chloride and 8.7 g (0.041 mol) of 6-bromohexanoyl chloride in 60 mL of methylene chloride cooled in an ice bath. The resulting solution was kept at 0 for 5 hours and then worked up as in Example 131. The crude product was recrystallized from methylene chloride-ether to give 6.98 g (62% yield), mp 81-83, of 6-bromo-1-(2-fluoro-4,5-dimethoxyphenyl)-1-hexanone. The nmr spectrum was consistent with the structure and the mass spectrum gave a molecular ion at m/z 332 (C14 H18 BrFO3).
Statistics shows that 398-62-9 is playing an increasingly important role. we look forward to future research findings about 4-Fluoro-1,2-dimethoxybenzene.
Reference:
Patent; Hoffmann-La Roche Inc.; US5025036; (1991); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem