These common heterocyclic compound, 35822-58-3, name is 2-Bromobenzaldehyde diethyl acetal, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 35822-58-3
General procedure: A mixture of p-anisaldehyde (2.00 g, 1.79 mL, 14.7 mmol), thiourea (3.35 g, 44.1 mmol, 3.0 equiv), and ethyl acetoacetate (5.73 g, 5.56 mL, 44.0 mmol, 3.0 equiv) in isopropanol (20 mL) was stirred at room temperature as iron(III) tosylate (0.497 g, 0.734 mmol, 5.0 mol %) was added. The reaction mixture was heated at 70 C (temperature controlled hot plate). After 15 h, the mixture was cooled to room temperature. The solvent was then removed on a rotary evaporator, and the residue was recrystallized (ethanol) to yield 5.48 g of an off-white solid. This solid was then triturated using methanol/water (1:1) to yield 3.75 g (83%) of a light off-white solid.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 35822-58-3.
Reference:
Article; Starcevich, Jacob T.; Laughlin, Thomas J.; Mohan, Ram S.; Tetrahedron Letters; vol. 54; 8; (2013); p. 983 – 985;,
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