Adding a certain compound to certain chemical reactions, such as: 437-83-2, name is 3-Fluoro-2-methoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 437-83-2, 437-83-2
NaNO2 (12.0 g, 1?73 mmol, in 40 m of water) solution was added dropwise to the mixture of 3-fluoro-2-methoxyaniline (20.0 g, 158 mmol) in 200 m of hydrobromic acid (4?7 %) and 100 m of water at -5 o Oc and stirred for 1 hour.This solution was then added slowly to the suspension of cuBr (45.2 g, 315 mmol) in 50 m of hydrobromic acid (4?7 %) at O Oc. The resulting mixture was stirred at o Oc for 1 hour then warmed to so Oc and stirred for 1 hour. The reaction mixture was poured into ice water and extracted with ether (2 X 500 mL). The combined organie layer was washed with brine, dried oyer anhydrous Na2504 and concentrated to giye 1-bromo-3-fluoro-2-methoxybenzene.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Fluoro-2-methoxyaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DE JESUS, Reynalda, Keh; DING, Fa-xiang; DONG, Shuzhi; FRIE, Jessica; GU, Xin; JIANG, Jinlong; SHAHRIPOUR, Aurash; PIO, Barbara; TANG, Haifeng; WALSH, Shawn; WO2014/126944; (2014); A2;,
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