Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 946-80-5, name is Benzyl Phenyl Ether, This compound has unique chemical properties. The synthetic route is as follows., 946-80-5
A. 4-Benzyloxybenzenesulfonyl chloride To 0.87 g of dimethylformamide, at 0 C. under an atmosphere of nitrogen, was added 1.61 g of sulfuryl chloride. The mixture was stirred for 15 min and treated with 2.00 g of benzyl phenyl ether. The mixture was then heated at 100 C. for 1.5 h, cooled to about 40 C., poured onto ice, extracted with CH2 Cl2, dried over MgSO4, filtered, and concentrated in vacuo. The residue was purified by low pressure silica gel chromatography using 10% ethyl acetate in hexane as eluent to provide 0.78 g of the title product as a white solid. TLC: Rf=0.46, 10% ethyl acetate in hexane. (1 H)-NMR (CDCl3) consistent with structure.
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Reference:
Patent; Vertex Pharmaceuticals, Incorporated; US5783701; (1998); A;,
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