22236-10-8, The chemical industry reduces the impact on the environment during synthesis 22236-10-8, name is 4-(Difluoromethoxy)aniline, I believe this compound will play a more active role in future production and life.
Example 26 1- [(6-Aminopyridin-3-yl)methyl]-3-{[4-(diffuromethoxy)phenyl]amino}-4-phenyl- 1H-PYRROLE-2, 5-dione A mixture of tert-butyl {5- [ (3-chloro-2, 5-dioxo-4-phenyl-2, 5-dihydro-lH-pyrrol-l- yl) methyl]pyridin-2-yl} carbamate (0.70 g, 1.7 mmol) and 4- (difluoromethoxy)-aniline (0.54 g, 3.4 mmol) in DMF (4 mL) was heated in a microwave reactor at 150C for eight min.. The sovent was evaporated and the residue was purified on a column (ISOLUTE SI, LOG/70 mL), using CH2Cl2 and then CH30H/CH2C12 (1: 99,2 : 98 and then 5: 95) as eluant, to give 0.4 g (54%) of the title COMPOUND. 1H NMR (400 MHz, CDC13) 8 7.99 (bs, 1H), 7.67-7. 62 (m, 2H), 7.14-7. 04 (m, 3H), 6.91 (d, J =8 Hz, 2H), 6.78 (d, J=8 Hz, 1H), 6.72 (d, J=9 Hz, 2H), 6.63 (d, J=9 Hz, 2H), 6.33 (t, J=74 Hz, 1H), 4.60 (s, 2H).
The chemical industry reduces the impact on the environment during synthesis 4-(Difluoromethoxy)aniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ASTRAZENECA AB; WO2005/5417; (2005); A1;,
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