101-55-3, Adding some certain compound to certain chemical reactions, such as: 101-55-3, name is 1-Bromo-4-phenoxybenzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 101-55-3.
General procedure: Reactions were conducted using standard dry box techniques and all solvents were distilled over Reactions were conducted using standard dry box techniques and all solvents were distilled oversodium. Method A: To a screw capped vial was added Pd(dba)2 (0.010 mmol), DTBNpP(0.020mmol), and NaH (1.2 mmol). The vial was sealed with a septa screw cap and removedfrom the glove box. To the vial was added toluene (1.0 mL), aryl bromide (1.0 mmol), anddiethyl malonate (1.2 mmol). The reaction mixture was stirred at 70 C for 24 hours and theconversion of the aryl bromide was then measured by GC. The crude reaction mixture wasfiltered through a plug of Celite and then concentrated in vacuo. The concentrate was thenpurified by column chromatography on silica gel.Reactions were conducted using standard dry box techniques and all solvents were distilled oversodium. Method A: To a screw capped vial was added Pd(dba)2 (0.010 mmol), DTBNpP(0.020mmol), and NaH (1.2 mmol). The vial was sealed with a septa screw cap and removedfrom the glove box. To the vial was added toluene (1.0 mL), aryl bromide (1.0 mmol), anddiethyl malonate (1.2 mmol). The reaction mixture was stirred at 70 C for 24 hours and theconversion of the aryl bromide was then measured by GC. The crude reaction mixture wasfiltered through a plug of Celite and then concentrated in vacuo. The concentrate was thenpurified by column chromatography on silica gel.Reactions were conducted using standard dry box techniques and all solvents were distilled oversodium. Method A: To a screw capped vial was added Pd(dba)2 (0.010 mmol), DTBNpP(0.020mmol), and NaH (1.2 mmol). The vial was sealed with a septa screw cap and removedfrom the glove box. To the vial was added toluene (1.0 mL), aryl bromide (1.0 mmol), anddiethyl malonate (1.2 mmol). The reaction mixture was stirred at 70 C for 24 hours and theconversion of the aryl bromide was then measured by GC. The crude reaction mixture wasfiltered through a plug of Celite and then concentrated in vacuo. The concentrate was thenpurified by column chromatography on silica gel.Reactions were conducted using standard dry box techniques and all solvents were distilled oversodium. Method A: To a screw capped vial was added Pd(dba)2 (0.010 mmol), DTBNpP(0.020mmol), and NaH (1.2 mmol). The vial was sealed with a septa screw cap and removedfrom the glove box. To the vial was added toluene (1.0 mL), aryl bromide (1.0 mmol), anddiethyl malonate (1.2 mmol). The reaction mixture was stirred at 70 C for 24 hours and theconversion of the aryl bromide was then measured by GC. The crude reaction mixture wasfiltered through a plug of Celite and then concentrated in vacuo. The concentrate was thenpurified by column chromatography on silica gel.Reactions were conducted using standard dry box techniques and all solvents were distilled oversodium. Method A: To a screw capped vial was added Pd(dba)2 (0.010 mmol), DTBNpP(0.020mmol), and NaH (1.2 mmol). The vial was sealed with a septa screw cap and removedfrom the glove box. To the vial was added toluene (1.0 mL), aryl bromide (1.0 mmol), anddiethyl malonate (1.2 mmol). The reaction mixture was stirred at 70 C for 24 hours and theconversion of the aryl bromide was then measured by GC. The crude reaction mixture wasfiltered through a plug of Celite and then concentrated in vacuo. The concentrate was thenpurified by column chromatography on silica gel.sodium. Method A: To a screw capped vial was added Pd(dba)2 (0.010 mmol), DTBNpP(0.020mmol), and NaH (1.2 mmol). The vial was sealed with a septa screw cap and removedfrom the glove box. To the vial was added toluene (1.0 mL), aryl bromide (1.0 mmol), anddiethyl malonate (1.2 mmol). The reaction mixture was stirred at 70 C for 24 hours and theconversion of the aryl bromide was then measured by GC. The crude reaction mixture wasfiltered through a plug of Celite and then concentrated in vacuo. The concentrate was then purified by column chromatography on silica gel.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 101-55-3.
Reference:
Article; Semmes, Jeffrey G.; Bevans, Stephanie L.; Mullins, C. Haddon; Shaughnessy, Kevin H.; Tetrahedron Letters; vol. 56; 23; (2015); p. 3447 – 3450;,
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