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A compound of formula 6a (20.50 g, 100 mmol), 7a (15.62 g, 120 mmol) and dimethyl sulfoxide (102 mL) were added to a three-neck flask.After stirring and stirring, cuprous iodide (1.90 g, 10 mmol), L-valine (1.15 g, 10 mmol), potassium carbonate (27.64 g, 200 mmol),Vacuum switching nitrogen 3 times,The temperature is raised to 45 to 50 C for 6 to 8 hours.After completion of the reaction, the reaction was quenched by the addition of ammonium chloride solution (204 mL), and extracted with ethyl acetate (102 mL), and the organic phase was combined and washed with saturated brine.Then, dry anhydrous sodium sulfate, concentrated to remove some solvent under reduced pressure, add petroleum ether to be beaten, filter, collect solids and dry to produce Product 8a (21.66 g, 74%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Hangzhou Kechao Biological Technology Co., Ltd.; Zheng Xuchun; Zhang Yiping; Fu Chenchen; (12 pag.)CN108586359; (2018); A;,
Ether – Wikipedia,
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