Simple exploration of 888327-32-0

Related Products of 888327-32-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 888327-32-0, name is 4-Bromo-1-(difluoromethoxy)-2-methylbenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 2: ((4-(Difluoromethoxy)-3-methylphenyl)ethvnyl)trimethylsilane; In a 250 mL round-bottomed flask was placed 4-bromo-1-(difluoromethoxy)-2- methylbenzene (14 g, 59.1 mmol) from the previous step. Pyrrolidine (23.6 mL) and acetonitrile (35.4 mL) were added to give a colorless solution. The reaction was degassed by bubbling with N2. Ethynyltrimethylsilane (7.0 g, 10 mL, 70.9 mmol) was added followed by bis(triphenylphosphine)dichloropalladium (2.07 g, 2.95 mmol) and copper(l) iodide (0.56 g, 2.95 mmol) was added. The reaction was warmed to 65 0C for 4h. The reaction was cooled. The solution was partitioned between EtOAc (200 mL) and 1 M HCI (200 ml_). The organic was washed with 1M HCI (200 mL) and brine (200 mL). The organic layer was dried over Na2SO4 and filtered. The solvent was removed and the resulting crude material was purified by flash chromatography (SiO2, 100% hexanes) to provide 12.4 g, 83%, of the title compound as a light yellow oil.

The synthetic route of 4-Bromo-1-(difluoromethoxy)-2-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WYETH; WO2008/115552; (2008); A1;,
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