In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 349-55-3, name is 3-Methoxy-5-(trifluoromethyl)aniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C8H8F3NO
d) Preparation of Intermediate 4 3-Methoxy-5-(trifluoromethyl)benzenamine (20 g, 104.6 mmol) was added portion-wise to a cooled solution of NaNO2 (7.392 g, 107.1 mmol) in H2SO4 (74 ml) and CH3COOH (88 ml). This mixture was added dropwise to a vigorously stirred solution of CuBr (18 g, 62.8 mmol) in 48% HBr (200 ml) at 0 C. The r.m. was stirred for 45 min at r.t. and was then poured into ice-water. This aqueous mixture was extracted with DCM. The separated organic layer was dried (MgSO4), filtered and the solvent was evaporated at low temperature. The residue was stirred in a NaHCO3 solution and extracted with DIPE. The separated organic layers was dried (MgSO4), filtered and the solvent was evaporated. Yield: 12.7 g of intermediate 4 (yield 48%).
The synthetic route of 349-55-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MacDonald, Gregor James; Thuring, Johannes Wilhelmus John F.; Van den Keybus, Frans Alfons Maria; Van Roosbroeck, Yves Emiel Maria; US2012/172354; (2012); A1;,
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