Reference of 2339-58-4, The chemical industry reduces the impact on the environment during synthesis 2339-58-4, name is 3-Fluoro-5-methoxyaniline, I believe this compound will play a more active role in future production and life.
A solution of 3-fluoro-5-methoxyaniline (800 mg, 5.67 mmol) in DMF (20 ml) was treated with NBS (1 g, 5.67 mmol) and the reaction mixture stirred at r.t. for 1 hr. The reaction mixture was treated with water and ethyl acetate. The phases were separated and the aqueous phase extracted with additional ethyl acetate. The combined organic phases were washed with water and brine, dried over sodium sulfate and concentrated. The residue was purified by Biotage Isolera (10-50% ethyl acetate in hexanes) to provide the desired product as an off white solid (1.05 g, 84%). LCMS calculated for C7H8BrFNO (M+H)+: m/z=220.0/222.0; Found: 220.0/222.0.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Fluoro-5-methoxyaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Incyte Corporation; Sokolsky, Alexander; Vechorkin, Oleg; Wang, Anlai; Ye, Qinda; Yao, Wenqing; (77 pag.)US2019/256520; (2019); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem