In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 651734-54-2, name is 2,6-Difluoro-3,5-dimethoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 651734-54-2
A mixture of intermediate 11 (1.4g; 4.6 mmol), 2,6-difluoro-3,5-dimethoxyaniline (1.4 g;7.3 mmol), Brettphos palladacycle (0.18 g; 0.23 mmol) and cesium carbonate (4.5 g; 14mmol) in toluene (60 mL) was heated at 100 00 overnight. The mixture was cooled, poured onto cooled water and EtOAc was added. The solution was filtered through a pad of Celite (diatomaceous earth) and the product was extracted with EtOAc. The organic layer was dried over MgSO4, filtered and evaporated to dryness.The residue (2.6 g) was purified by chromatography over silica gel (irregular SiOH,300 g; mobile phase: 60% heptane, 5% MeOH, 35% EtOAc). The fractions containingthe product were collected and evaporated to dryness yielding 1.1 g of an intermediatewhich was crystallized from Et20 yielding 1.06 g (56 %) of intermediate 22.MP = 214C (DSC)
The synthetic route of 651734-54-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTEX THERAPEUTICS LIMITED; ANGIBAUD, Patrick Rene; QUEROLLE, Olivier Alexis Georges; PILATTE, Isabelle Noelle Constance; MEERPOEL, Lieven; PONCELET, Virginie Sophie; WO2014/174307; (2014); A1;,
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