Synthetic Route of 145903-31-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 145903-31-7, name is 7-Methoxy-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine, This compound has unique chemical properties. The synthetic route is as follows.
As Scheme 3 demonstrates, 2-chloroethanesulfonyl chloride (180 mg; 1.1 mM) and Et3N (140 mg; 1.1 mM) were added to 7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (1) (194 mg; 1 mM) in CH2Cl2 (20 ml), at 0 C. The mixture was stirred at 0 C. for 2 h, and washed with H2O and saturated NaHCO3 solution. Removal of the solvent gave crude product (Ia), which was purified by chromatography on silica gel (petroleum ether:ethyl acetate=3:1). The yield from this synthesis was 280 mg, or 95%. The structure was confirmed by NMR.
The chemical industry reduces the impact on the environment during synthesis 7-Methoxy-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Marks, Andrew R.; Landry, Donald W.; Deng, Shi Xian; Cheng, Zhen Zhuang; US2005/215540; (2005); A1;,
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