Synthetic Route of 143-24-8,Some common heterocyclic compound, 143-24-8, name is 2,5,8,11,14-Pentaoxapentadecane, molecular formula is C10H22O5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
At room temperature, a 450 ml Parr reactor was filled with methanol and 5 mmole of Co2(CO)8. The reactor was filled with CO gas at 500 psig, heated to 80 C. and agitated for one hour. Then the reactor was cooled to room temperature and imidazole as promoter was added to the reactor. Ethylene oxide was added to the reactor and CO was added at a predetermined pressure. The reactor was heated to a temperature as shown in Table 1 at a pressure as in Table 1 for the time as in Table 1. During the reaction, the reaction product was sampled using a tube. As product, methyl 3-hydroxypropionate (3-HPM) was analyzed with a GC. The reaction conditions and the resulting data are shown in Table 1. Imidazole of 20 mmole as promoter was used in Examples 1-7 and 9, 40 mmole in Example 8, and 30 mmole in Example 10. Ethylene oxide of 500 mmole was used in Examples 1-8 and 10, and 1.4 mmole in Example 9. In Example 7, tetraglyme was used besides methyl alcohol.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,5,8,11,14-Pentaoxapentadecane, its application will become more common.
Reference:
Patent; Samsung Electronics Co. Ltd.; US6348632; (2002); B1;,
Ether – Wikipedia,
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