Electric Literature of 41406-00-2,Some common heterocyclic compound, 41406-00-2, name is 3-Isopropoxyaniline, molecular formula is C9H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 11 Preparation of 3′-iso-propoxy-2-methylbenzanilide A 13.6 g (0.1 mol) portion of o-methylbenzoic acid, 15.1 g (0.1 mol) of m-isopropoxyaniline and 10.1 g (0.1 mol) of triethylamine were dissolved in 100 ml of xylene. A 5.1 g (0.033 mol) amount of phosphorus oxychloride was added dropwise to the prepared solution with stirring at 90-100C. Stirring of the resulting solution was continued at 90-100C for 3 hours. The reaction mixture was cooled and washed with water, and the product was dried over anhydrous sodium sulfate. The xylene was removed to obtain 20.9 g (77.9%) of white prismatic crystals having a melting point of 92-94C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Isopropoxyaniline, its application will become more common.
Reference:
Patent; Kumiai Chemical Industry Co., Ltd.; US3937840; (1976); A;,
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