Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4698-11-7, name is 10-Methoxy-5H-dibenzo[b,f]azepine, A new synthetic method of this compound is introduced below., SDS of cas: 4698-11-7
Example 1 Step 1. Preparation of 10-Methoxy-5H-dibenz [b, f] azepine-5-carbonyl chloride 100 gms of 10 Methoxy iminostilbene is dissolved in 300 mi chloroform & cooled to 0 C Bis (trichlor methyl) carbonate (BTC) 65 gms is added. 67 gms of triethyl amine (TEA) in 100 ml chloroform is added slowly over a period of6 hour & maintaining the temperature 0-5C. Temperature is then increased to 25-30 C 1& maintained for 8 hour. The reaction mixture is poured into 300 mi water & layers are separated. Chloroform is evaporated 10-Methoxy-5H-dibenz [b, f] azepine-5-carbonyl chloride is isolated in methanol. Yield obtained is 110 gms (86%) of theoretical.Example 3 Step 1. Preparation of 10-Methoxy-5H-dibenz [b, f] azepine-5-carbonyl chloride 100 gms of 10-Methoxy iminostilbene is dissolved in 300 ml chloroform & cooled to 0C and 45 gms Bis (trichlor methyl) carbonate (BTC) is added followed by he addition of 45 gms-of-TEA in 100 ml chloroform over a period-of 8 hours maintaining the temperature at 0-5C. The temperature is then increased to 25-30C & maintained for 2 hours. The reaction mixture is poured into 300 ml water layers are separated. Chloroform is evaporated & product is isolated in methanol. Yield obtained is 100 gms (80% of theoretical).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; AMOLI ORGANICS LTD.; WO2005/66133; (2005); A2;,
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