Adding a certain compound to certain chemical reactions, such as: 349-65-5, name is 2-Methoxy-5-(trifluoromethyl)aniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 349-65-5, Computed Properties of C8H8F3NO
To a solution of phosgene (1.93 M in toluene; 16 mL, 31.4 mmol) in CH2Cl2 (120 mL) at 0 C was added a solution of 2-methoxy-5-(trifluoromethyl)aniline (3.0 g, 15.7 mmol) and pyridine (2.3 mL, 47.1 mmol) in CH2Cl2 (30 mL) dropwise. The resulting mixture was stirred at 0 C for 30 min and at room temp for 3 h, then concentrated under reduced pressure. The residue was diluted with toluene (30 mL), concentrated under reduced pressure, and treated with Et2O. The resulting precipitate (pyridinium hydrochloride) was removed and the filtrate was concentrated under redeuced pressure to give the title compound as a yellow oil (3.0 g) which crystallized upon standing at room temp. for a few days.
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Reference:
Patent; Bayer Corporation; EP1449834; (2004); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem