Synthetic Route of 57478-19-0, These common heterocyclic compound, 57478-19-0, name is 4-(4-(Trifluoromethyl)phenoxy)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of benzoic acid derivatives (5 or 9 or 15 or 19, 1.0 equiv.) and HATU (1.1 equiv.) in DMF at room temperature, substituted amine (1.05 equiv.) and DIPEA (1.2 equiv.) were added sequentially. The reaction mixture was stirred at room temperature for 1-2h. The resulting mixture was diluted with 5% HCl, and extracted with EtOAc. The combined organic layers were washed with saturated aqueous NaHCO3 and brine, dried over anhydrous Na2SO4, concentrated, and recrystallized from MeOH to afford the crude product.
The synthetic route of 57478-19-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Xie, Fangzhou; Liang, Yaoyao; Xia, Yu; Luo, Shuhua; Jiang, Faqin; Fu, Lei; Bioorganic Chemistry; vol. 92; (2019);,
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