Application of 113421-98-0,Some common heterocyclic compound, 113421-98-0, name is 4-Fluoro-3-(trifluoromethoxy)aniline, molecular formula is C7H5F4NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-bromo-6-acetylamino-1H-indole-2-carboxylic acid ethyl ester (100 mg, 0.31 mmol), Pd2 (dba) 3 (28 mg, 0.031 mmol), X-phos (30 mg, 0.062 mmol), Cs2CO3 (301 mg, 0.92 mmol) and 3-trifluoromethoxy-4-fluoroaniline (172 mg, 0.92 mmol) were added to a microwave tube, dissolved in 1,4-dioxane (2 mL), and filled with argon Gas-protected, microwave reaction at 100 C for 0.5h, the raw materials disappeared. Cool to room temperature, add EA (20mL), wash with saturated brine (20mL ¡Á 3), wash with water (20mL ¡Á 2), and column chromatography (P / E = 2: 1) to obtain 84mg of a white solid with a yield of 62.2% and a melting point. : 205-206 C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Fluoro-3-(trifluoromethoxy)aniline, its application will become more common.
Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Xu Boling; Chen Xiaoguang; Cui Guonan; Lai Fangfang; Zhou Jie; Ji Ming; Wang Xiaoyu; Du Tingting; Li Ling; Jin Jing; (144 pag.)CN110483366; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem