148583-65-7, name is 4-Fluoro-2-isopropoxyaniline, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C9H12FNO
Intermediate 29 Ethyl 7-chloro-4-{[4-fluoro-2-(propan-2-yloxy)phenyl]amino}-5-methyl^ d]pyrimidine-6-carboxyla te A mixture of Intermediate 28 (320 mg, 1.17mmol), 4-fluoro-2-isopropoxyaniline (179 muIota, 1.17 mmol) and PTSA (22 mg, 0.117 mmol) in IPA (15 ml) was stirred and heated at 60″C for 3 hours. The reaction was allowed to cool to rt and then concentrated to dryness. The residue was diluted with DCM and washed with sat. NaHCOs (aq). The aqueous phase was re-extracted with DCM. The combined organic phases were dried and concentrated. The crude product was pre-absorbed on to silica gel prior to purification by flash chromatography on silica gel eluting with 40:1 DCM: IPA to give a pale beige coloured solid (395 mg, 83 %). 1H NMR (400 MHz, DMSO-d6) delta ppm 1 ,27 (d, J=5.95 Hz, 6 H), 1.38 (t, J=7.10 Hz, 3 H), 4.31 (s, 3 H), 4.37 – 4.47 (m, 2 H), 4.73 (dt, J=12.02, 6.13 Hz, 1 H), 6,77 – 6.86 (m, 1 H), 7.07 (dd, J=10.99, 2.75 Hz, 1 H), 8.27 (dd, J=8.70, 6.41 Hz, 1 H), 8.38 (s, 1 H), 8.43 (s, 1 H)
The synthetic route of 148583-65-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MEDICAL RESEARCH COUNCIL TECHNOLOGY; WINTER-HOLT, Jon James; MCIVER, Edward Giles; LEWIS, Stephen; OSBORNE, Joanne; (106 pag.)WO2017/85483; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem