In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4342-46-5, name is 4-Methoxycyclohexanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 4-Methoxycyclohexanamine
Water is added to the high-pressure reaction kettle 1200 ml, opening stirring, add concentration is 40% formamide 220 g (2 muM), stirring 10 min after, adding 1 – amino -4 – methoxy cyclohexane 130 g (1 muM), then adding carbon catalyst 7 g, in the reaction kettle access CO, make the kettle pressure reaches 0.2 mpa, heating to 50 C, thermal insulation 20 h, when the reaction solution 1 – amino -4 – methoxy cyclohexane content of less than 2% when the end of the reaction, lowering the temperature to 25 – 30 C, adding diluted hydrochloric acid to the reaction in the fluid drops, adjust the pH to 5 – 6, solids are separated out, to filter out the product, the filter cake washed mixing, cis – 8 – be methoxy – 1, 3 – diaza spiro [4, 5] decan – 2, 4 – dione dry – 155 g, yield 78%
The synthetic route of 4342-46-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Henan Zi Wei Xing Chemical Co., Ltd.; Mao Longfei; Wu Doucan; Li Wei; Lu Zhiguo; Wang Zhenggang; Lu Biao; Jia Shuhong; Yuan Zhiguo; (10 pag.)CN107857722; (2018); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem