Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7664-66-6, name is 4-Isopropoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C9H13NO
Phenyl chloroformate (15.2 kg, 97.1 mol) was dissolved in toluene (115.7 kg) and cooled to 3 0C. 4-isopropoxyaniline (III) (13.3 kg, 88.0 mol) was mixed with acetonitrile (43.4 kg) and slowly added to the phenyl chloroformate solution over 1 hour 40 minutes, followed by slow addition of triethylamine (9.8 kg, 96.8 mol) over 46 minutes. The mixture was heated to 17.5 0C and stirred for 3 hours 30 minutes until the reaction was deemed complete by HPLC. The product solution was washed with IN HCl, followed by removing acetonitrile though an azeotropic distillation with additional toluene (52.3 kg). The solution was heated to 58 0C before slowly adding heptane (43.7 kg) over 1 hour 2 minutes, after which the slurry was cooled to 23.5 0C over 2 hours 35 minutes and stirred for an additional 2 hours 51 minutes. The material was isolated, washed twice with heptane, and dried at < 40 0C for 3 hours 49 minutes. The product was discharged, yielding 19.1kg of the title compound (HIa) (80% yield, 100% purity HPLC AUC). 1H NMR (300 MHz, CD3OD, delta): 7.38 (m, 4H), 7.19 (m, 3H), 6.86 (d, J = 9Hz 2H), 4.52 (sept, J = 6Hz, IH), 1.28 (d, J = 6Hz, 6H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7664-66-6.
Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC; ARMITAGE, Ian; BOURLAND, Michael, E.; BOYLE, Craig, J.S.; COOPER, Martin, Ian; FERDOUS, Abu, J.; LANGSTON, Marianne; WO2010/59239; (2010); A2;,
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