These common heterocyclic compound, 7025-06-1, name is 1-Bromo-2-phenoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1-Bromo-2-phenoxybenzene
30 g of 1-bromo-2-phenoxybenzene was dissolved in 300 ml of anhydrous tetrahydrofuran under a nitrogen atmosphere,-78 ¡ã CRespectively.to the next,48 ml of 2.5 M-butyllithium was slowly added dropwise.After completion of the dropwise addition, stirring was performed for 30 minutes,2-Bromofluorene 31.2 gWas dissolved in 200 ml of absolute tetrahydrofuran and then slowly added dropwise.The reaction solution was maintained at -78 ¡ã C for about 1 hour, then warmed to room temperature and stirred for 12 hours.The reaction was terminated by adding diluted hydrochloric acid to the reaction solution, followed by liquid fraction extraction using methylene chloride.The obtained organic layer was dried with magnesium sulfate, filtered, and then distilled under reduced pressure. to the next,After adding 400 ml of acetic acid, a catalytic amount of hydrochloric acid was added dropwise, followed by stirring at a reflux temperature for 12 hours.After completion of the reaction, the reaction mixture was cooled to obtain a solid,After filtration, 32.0 g of compound AA was obtained by column chromatography.
The synthetic route of 1-Bromo-2-phenoxybenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG CHEM, LTD.; HONG, WAN PYO; KWON, HYOK JOON; KIM, KONG KYEOM; KIM, MIN JUN; KIM, SEONG SO; (79 pag.)KR2017/59910; (2017); A;,
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