In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 70894-71-2, name is N-(4-Methoxybenzyl)cyclopropanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of N-(4-Methoxybenzyl)cyclopropanamine
6,8-Dichloroimidazo[l,2-b]pyridazine-3-carboxamide (2.5 g, 10.9 mmol), N-(4- methoxybenzyl)cyclopropanamine (3.36 g, 18.98 mmol) and diisopropylethylamine (4.42 ml, 25.3 mmol) were dissolved in tetrahydrofuran (THF, 100 mL) and then refluxed overnight. The solvent was removed in vacuo and the crude product was taken up in chloroform and purified via chromatography to provide the product (2.6 g, 64% yield). NMR (400 MHz, DMSO-D6) delta ppm 8.10 (1 H, s), 7.96 (2 H, s), 7.11 (2 H, d, J=8.56 Hz), 6.83 (2 H, d, J=8.81 Hz), 6.73 (1 H, s), 5.65 (2 H, s), 3.68 (3 H, s), 2.55 – 2.63 (1 H, m), 0.93 – 1.03 (2 H, m), 0.76 – 0.84 (2 H, m).
The synthetic route of 70894-71-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WEINSTEIN, David S.; MOSLIN, Ryan M.; ZHANG, Yanlei; GARDNER, Daniel S.; SANTELLA, Joseph B.; LANGEVINE, Charles M.; STACHURA, Sylwia; (127 pag.)WO2017/87590; (2017); A1;,
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