Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 801282-00-8, name is 2-Fluoro-3-methoxyaniline, A new synthetic method of this compound is introduced below., Safety of 2-Fluoro-3-methoxyaniline
Preparation of compound 10[00177] To a solution of compound 9 (13 g, 92 mmol) in DMF (100 mL) was added a solution of NBS (16.4 g, 92 mmol, 1.0 eq) in DMF (100 mL) drop-wise. The reaction mixture was stirred at room temperature for 3h, then diluted with ethyl acetate (500 mL) and washed with brine (2xl50mL). The organic phase was dried (Na2S04), filtered and concentrated to give the title compound (10) as brown oil (23 g, 98%) yield). ESI-MS (M+H)+: 219.9.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; TONG, Youzhi; WO2011/29392; (2011); A1;,
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