Synthetic Route of 91273-58-4,Some common heterocyclic compound, 91273-58-4, name is ((3-Bromo-2-methylpropoxy)methyl)benzene, molecular formula is C11H15BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 5 rac. 4-Benzyloxy-3-methylbutyronitrile A solution of 3.38 g. (0.069 mole) of sodium cyanide and 8.4 g. (0.0345 mole) of rac. 3-benzyloxy-2-methyl-1-propyl bromide in 11.5 ml. of water and 45 ml. of ethanol was stirred and heated at reflux for 20 hours. The reaction mixture was cooled, diluted with water and the product was isolated by extraction with benzene and worked up as in Example 1. This afforded 6.4 g. of oily residue which was chromatographed on 350 g. of silica gel. Elution with 4:1 parts by volume and 2:1 parts by volume hexane: ether gave 5.8 g. (89%) of pure rac. 4-benzyloxy-3-methylbutyronitrile as a yellow oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route ((3-Bromo-2-methylpropoxy)methyl)benzene, its application will become more common.
Reference:
Patent; Hoffmann-La Roche Inc.; US4041058; (1977); A;,
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