Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32338-02-6, name is 2-Bromo-4-methoxyaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 32338-02-6
General procedure: Appel?s salt and an aniline were allowed to stir in CH2CI2 (DCM) for 1 h at room temperature under a nitrogen atmosphere. The solution was then cooled to below 5 00 and base (preferably DBU orDBN) was added, dropwise over 30 mm, to the stirring solution maintained at 5 00 all under a nitrogen atmosphere. After the addition, the resulting mixture was stirred for 30 mm while allowing it to warm to room temperature, after which it was ref luxed at 40 C for 4 h. Upon cooling to room temperature (rt), ethyl acetate (EtOAc) was added. The reaction mixture was then washed with saturated NH4CIaq solution, and H20. The organic phase was dried over Na2SO4 and concentratedin vacuo. The crude material was purified by silica gel chromatography to provide the corresponding benzothiazoles.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; UNIVERSITY OF CAPE TOWN; JARDINE, Moegamat Anwar; RYLANDS, Marwaan; (60 pag.)WO2019/21202; (2019); A1;,
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