Related Products of 5467-58-3,Some common heterocyclic compound, 5467-58-3, name is 1-Bromo-4-methoxynaphthalene, molecular formula is C11H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under a nitrogen atmosphere, into a 250 mL three-necked flask equipped with a magnetic stirrer, a thermometer, and a condenser, 6.6 g (27.9 mmol) of 1-bromo-4-methoxynaphthalene and 12.0 g (36.3 mmol) of 4- were added. Nitrophenyl-2-amino-9,9-dimethylhydrazine,10.6g (167.4mmol) of copper powder, 23.1g (167.4mmol) of potassium carbonate, 7.4g (27.9mmol) of 18-crown-6, then add 57.2ml of o-dichlorobenzene, react at 170 C for 20h; Filtration, distillation of o-dichlorobenzene under reduced pressure, and the obtained crude product was ethanolRecrystallization with N,N-dimethylacetamide (V:V = 1:2.7),4-nitrophenyl-4′-methoxynaphthyl-2-amino-9,9-dimethylfluorene 10.2 g, yield 75%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-methoxynaphthalene, its application will become more common.
Reference:
Patent; Jilin University; Chen Chunhai; Su Kaixin; Wang Daming; Sun Ningwei; Zhou Hongwei; Zhao Xiaogang; (23 pag.)CN108912003; (2018); A;,
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