Adding a certain compound to certain chemical reactions, such as: 702-24-9, name is 4-Methoxy-N-methylbenzylamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 702-24-9, Safety of 4-Methoxy-N-methylbenzylamine
As shown in Scheme 3, 4-bromo-2,6-di-tert-butylphenyl tert-butyl carbonate5 (115 mg, 0.3 mmol, 1.0 equiv.), 1-(4-methoxyphenyl)-N-methylmethanamine (1.2 equiv.), Pd2(dba)3.CHCl3 (0.1 equiv.), xantphos (0.15 equiv.) and Cs2CO3 (2.5 equiv.) were weighed in a Biotage microwave reaction vial in a glove box. The mixture was treated with toluene (0.05 mM) and the vial was sealed and removed from the glove box. The reaction mixture was heated in an oil bath (100 C., 16 h). The crude mixture was cooled to room temperature and purified by silica gel chromatography using hexane and ethyl acetate as eluents to afford Compound 14 (98 mg, 71% yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methoxy-N-methylbenzylamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; The University of Kansas; Peterson, Blake R.; Rane, Digamber; (28 pag.)US2019/310263; (2019); A1;,
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