Application of 886762-08-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 886762-08-9, name is 5-Bromo-2-(trifluoromethoxy)aniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
N-(5-bromo-2-(trifiuoromethoxy)phenyl)acrylamide (2): To a solution of 5-bromo- 2-(trifiuoromethoxy)aniline (1.2 g, 4.7 mmol) in dichloromethane (5.0 niL), diisopropylethylamine (727 mg, 5.64 mmol) and acryloyl chloride (382 mg, 4.22 mmol) were added at -78 C. The reaction mixture was allowed to stir at 0 C for 2 h. After completion of the reaction, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 2 (1.4 g, 93%) as an off white solid. 1H NMR (400 MHz, DMSO-d6) : delta 5.79-5.80 (dd, J = 1.82 Hz, 10.2 Hz, 1H), 6.26-6.27 (dd, J = 1.8, 17.0 Hz, 1H), 6.61-6.63 (dd, J = 17.0 Hz, 1H), 7.38-7.40 (m, 2H), 8.28-8.29 (d, J = 2.3 Hz, 1H), 10.07 (brs, 1H). MS m/z (M+H): 310.45
The synthetic route of 5-Bromo-2-(trifluoromethoxy)aniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CELGENE AVILOMICS RESEARCH, INC.; ALEXANDER, Matthew David; MCDONALD, Joseph John; NI, Yike; NIU, Deqiang; PETTER, Russell C.; QIAO, Lixin; SINGH, Juswinder; WANG, Tao; ZHU, Zhendong; WO2014/149164; (2014); A1;,
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