Adding a certain compound to certain chemical reactions, such as: 93919-56-3, name is (4-(Trifluoromethoxy)phenyl)methanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 93919-56-3, category: ethers-buliding-blocks
Compound 25 (100 mg, 299.18 umol, 1.0 eq.), HATU (113.76 mg, 299.18 umol, 1.0 eq.) and triethylamine were dissolved in 2 mL of DCM in a 50 mL round-bottom flask. Compound B (114.38 mg, 598.36 umol, 2.0 eq.) was added and the reaction was kept at 25 C for 4 hours. LCMS detection reaction is complete. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by HPLC to give compound 8 as a white solid (80 mg, 157.67 umol, yield: 52.70%).
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Reference:
Patent; Shanghai Yaoming Kant, Immanuel New Drug Development Co., Ltd.; Wu Xiangyang; Wang Fei; Ao Zhiyong; Yang Kanghui; Wan Shuangyi; Wang Lijuan; (30 pag.)CN106478589; (2017); A;,
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