Electric Literature of 25245-34-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25245-34-5, name is 2-Bromo-1,4-dimethoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a suspension of sodium amide (8.5 g, 218 mmol) in anhydrous THF(100 mL) was added furan (59.3 g, 872 mmol) and the mixture warmed to 50 C under nitrogen. 4 (11 g,50.7 mmol) dissolved in anhydrous THF (20 mL) was added to the reaction mixture which was thenstirred at 50 C for 24 h. After cooled to room temperature, EtOAc (80 mL) and water (80 mL) wereadded to the solution. The organic layer was separated and washed with saturated aqueous NaCl and driedover anhydrous Na2SO4. The solvent was removed under reduced pressure to give a brown oil 5 withoutfurther purification which was dissolved in MeOH (100 mL) containing conc. hydrochloric acid (5 mL)and the mixture heated at reflux for 3 h. MeOH was removed under reduced pressure and the residue between EtOAc and water. The organic layer was washed with a solution of saturated aqueous NaHC03 and saturated aqueous NaCl in sequence and then dried over anhydrous Na2S04. The solvent was evaporated under reduced pressure and the residue was subjected to flash column chromatography (petroleum ether: EtOAc, 10:1, V/V) to give 6 (9.5 g, 91.3%) as white solid
The synthetic route of 2-Bromo-1,4-dimethoxybenzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhang, Qijing; Dong, Jinyun; Huang, Guang; Li, Shaoshun; Heterocycles; vol. 96; 2; (2018); p. 334 – 338;,
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