Reference of 5467-58-3, The chemical industry reduces the impact on the environment during synthesis 5467-58-3, name is 1-Bromo-4-methoxynaphthalene, I believe this compound will play a more active role in future production and life.
(0357) General procedure B: a mixture of 1-bromo-4-methoxynaphthalene (166 mg, 0.70 mmol), 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (164 mg, 0.70 mmol), K2CO3 (290 mg, 2.10 mmol) and [Iota, – bis(diphenylphosphino)ferrocene]palladium(II) dichloride (29 mg, 0.04 mmol) in dioxane (10 mL) and H2O (2 mL) was heated at 100 C overnight in an atmosphere of nitrogen. The reaction was then quenched with water and extracted with ethyl acetate. The combined organic layers were dried over magnesium sulfate, filtered and concentrated. The residue was purified by flash column chromatography on silica gel (eluent: dichloromethane/methanol, 0-10%) to give the title compound as light yellow solid (143 mg, 77% yield). ESI-MS m/z: 263.1075 [M-H]”; Punty: 93.6%. (0358) 1H NMR (400 MHz, chloroform- ) delta 8.35- 8.28 (m, 1H), 7.91 – 7.84 (m, 1H), 7.52 – 7.40 (m, 2H), 7.30 (d, J = 7.9 Hz, 1H), 7.25- 7.21 (m, 1H), 7.18 (dd, J = 8.0, 2.2 Hz, 1H), 6.87 (t, J= 8.0 Hz, 2H), 4.04 (s, 3H), 2.33 (s, 3H). 13C NMR (101 MHz, CDC13) delta 154.82, 153.02, 133.56, 132.98, 132.84, 132.58, 129.03, 126.82, 126.50, 126.02, 125.81, 125.16, 123.58, 122.27, 114.83, 103.56, 55.71, 15.99.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-methoxynaphthalene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE; YIN, Hang Hubert; ZHANG, Shuting; HU, Zhenyi; (114 pag.)WO2019/89648; (2019); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem