Synthetic Route of 156573-09-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 156573-09-0, name is 1-Bromo-4-ethoxy-2,3-difluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.
Third Step 4-Bromo-2,3-difluoroethoxybenzene (s-5) (45.2 g), 2, 3-difluorophenyllboronic acid (s-6) (36.1 g), potassium carbonate (79.1 g), Pd (Ph3P)2Cl2 (4.0 g), toluene (200 ml), Solmix A-11 (200 ml) and water (200 ml) were placed in a reaction vessel under an atmosphere of nitrogen, and heated to reflux for 2 hours. After the reaction solution had been cooled to 25C, it was poured into water (200 ml) and toluene (200 ml) and mixed with them. The mixture was then allowed to stand until it had separated into two layers of organic and aqueous layers, and the extraction into an organic layer was carried out. The resulting organic layers were separated, and washed with water, and then dried over anhydrous magnesium sulfate. The resulting solution was concentrated under reduced pressure. The resulting residue was purified by column chromatography using silica gel as a stationary phase powder and a mixed solvent of toluene and heptane (toluene: heptane= 2:1 by volume) as an eluent, and further purified by recrystallization from Solmix A-11 and dried to give 4-ethoxy-2,2′,3,3′-tetrafluoro-1,1′-biphenyl (s-7) (40.1 g).
The chemical industry reduces the impact on the environment during synthesis 1-Bromo-4-ethoxy-2,3-difluorobenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; JNC Corporation; JNC Petrochemical Corporation; EP2479162; (2012); A1;,
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