Adding a certain compound to certain chemical reactions, such as: 768-70-7, name is 3-Ethynylanisole, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 768-70-7, name: 3-Ethynylanisole
General procedure: A mixture of alkynes (0.24 mmol), sodium azide (0.24 mmol), halides (0.20 mmol) were added and stirred in glycerol (1.0 ml) in the presence of CuI (0.002 mmol) and diethylamine (0.01 mmol) at room temperature in a schlenk under nitrogen. The progress of the reaction was monitored by HPLC until the reaction was complete. The mixture was added water (10 ml) and extracted with ethyl acetate (3*20 mL). The onganic layer was dried over anhydrous Na2SO4. Then the residue was subjected to flash column chromatography on silica gel (petroleum ether/ethyl acetate) to afford the corresponding compounds 4.
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Reference:
Article; Guo, Shengqiang; Zhou, Yang; Dai, Bencai; Huo, Cuimeng; Liu, Changchun; Zhao, Yongde; Synthesis; vol. 50; 11; (2018); p. 2191 – 2199;,
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