Related Products of 701-07-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 701-07-5 as follows.
To a suspended solution of Mg chips (10.07 g, 0.414 mol) in anhydrous ether (150 mL) at 22C under argon was added ca. 0.15 mL of 1,2-dibromoethane. Then 43.7 g (0.200 mol) of 2-(isopropoxy)bromobenzene in 200 mL of ether was added dropwise. After 50% of the aryl halide was added, the reaction began to reflux vigorously. The flask was cooled in an ice bath. After the refluxing had subsided somewhat, the ice bath was removed and the remaining aryl halide was added over a 1.5 h period. The resultant Grignard reagent was cooled in a dry ice/ether bath for 2 h and then treated with 34.0 mL (0.221 mol) of 98% 1-carbethoxy-4-piperidone. Upon complete addition of ketone, the reaction mixture was allowed to warm to 22C and stirred for 2 h. The reaction was then quenched with cold aqueous ammonium chloride which resulted in an emulsion. Addition of 1M aqueous HCI solution separated the two layers. The aqueous phase was extracted with additional ether and the combined organic solution was washed with 10% aqueous sodium bisulfite, 1.0 M HCI, saturated NaHCO3, and dried (K2CO3). Filtration and concentration yielded 56.36 g of 1-carbethoxy-4-[2-(1-methylethoxy)phenyl]-4-piperidinol as a yellow viscous oil which was carried on without further purification The structure of this oil was supported by 1H NMR.
According to the analysis of related databases, 701-07-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ORTHO PHARMACEUTICAL CORPORATION; EP736009; (2002); B1;,
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