In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 74137-36-3 as follows. Safety of 1,3-Dibromo-5-methoxybenzene
Tris (dibenzylideneacetone) [DIPALLADIUM (0)] (6.53g, 7. [15MMOL)] was added in one portion to a stirred solution of the bromide of Preparation 1 (38. 0g, [143MMOL),] 1,1′-bis (diphenylphosphino) ferrocene (9.3g, 16. [8MMOL)] and zinc cyanide (20. 0g, [172MOL)] in N,N-dimethylformamide (300ml) at room temperature under nitrogen. The reaction was heated at [100¡ãC] for 14 hours and cooled to room temperature. Water (1500ml) was added and the mixture was extracted with ethyl acetate [(3X500ML).] The combined organics were filtered and the filtrate was washed with water (500ml), dried over magnesium sulphate, filtered and concentrated under reduced pressure. The resulting solid was triturated with toluene (1000ml) to provide the title compound (18. 0g) as a tan solid.
According to the analysis of related databases, 74137-36-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Pfizer Limited; Pfizer Inc.; WO2004/31156; (2004); A1;,
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