In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 456-49-5 as follows. Recommanded Product: 1-Fluoro-3-methoxybenzene
To a solution of n-butyllithium (2.6 M, n-hexane solution, 12.7 mL, 33 mmol) dissolved in THF (100 mL) was addeddropwise a solution of 3-fluoroanisole (3.44 mL, 31.1 mmol) dissolved in THF (10 mL) at -78 C. After stirring for 10min at the same temperature, to the mixture was added dropwise a solution of iodine (9.14 g, 36.0 mmol) dissolved inTHF (60 mL) at -78 C. After stirring for 30 min at the same temperature, to the mixture were added aqueous saturatedammonium chloride (20 mL) and then aqueous saturated sodium thiosulfate (40 mL). The mixture was extracted withn-hexane (20 mL ¡Á 3), and the combined organic extract was washed with brine (20 mL), dried (Na2SO4), and afterfiltration, the filtrate was concentrated under reduced pressure. The residue was purified by flash columnchromatography (silica-gel 156 g, n-hexane/EtOAc = 5/1) to give 3-fluoro-2-iodoanisole (7.03 g, 27.9 mmol, 93.0%) asa colorless oil.
According to the analysis of related databases, 456-49-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Yoshida, Suguru; Nagai, Akira; Uchida, Keisuke; Hosoya, Takamitsu; Chemistry Letters; vol. 46; 5; (2017); p. 733 – 736;,
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