Synthetic Route of 6358-77-6, The chemical industry reduces the impact on the environment during synthesis 6358-77-6, name is 5-Bromo-2-methoxyaniline, I believe this compound will play a more active role in future production and life.
Step 1: water (5 mL), boric acid (55 mg, 0.89 mmol) and glycerol (2-3 drops) were added to a stirred solution of 5-bromo-2-methoxyaniline (600 mg, 2.97 mmol) and divinylsulfone (351 mg, 2.97 mmol). The resulting mixture was stirred at reflux for 18h. The reaction mixture was cooled to rt and extracted withEtOAc. The organic layer was washed three times with water, dried over Mg504, filtered and the solution was evaporated under reduced pressure. Thecrude product was purified by silica gel column chromatography using Hexanes/EtOAc (50:50) as eluent yielding 4-(5-bromo-2-methoxyphenyl)-1- thiomorpholine-1,1-dione Ex.49a (900 mg, 95%). 1H NMR (400 MHz, DMSOd6, d in ppm): 3.22 (t, 4H, J=5.2Hz), 3.41-3.46 (m, 4H), 3.80 (s, 3H), 6.92-6.96(m, 1H), 7.12 (d, 1H, J=2.4Hz), 7.18 (dd, 1H, J=8.6Hz, J=2.4Hz).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-2-methoxyaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GENFIT; DELHOMEL, Jean-Francois; PERSPICACE, Enrico; MAJD, Zouher; PARROCHE, Peggy; WALCZAK, Robert; BONNET, Pascal; FOGHA, Jade; (144 pag.)WO2018/138359; (2018); A1;,
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