Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 702-24-9, name is 4-Methoxy-N-methylbenzylamine, A new synthetic method of this compound is introduced below., SDS of cas: 702-24-9
General procedure: A solution of 2-methyl-4-chlorocyclopenta[d]pyrimidine (17, 1eq.) and appropriate anilines or benzylamines (1.05 eq.) wereplaced in dioxane in a microwave vial. To the solution, HCl (2Nin dioxane, 1?2 drops) was added. The reaction mixture was setin a Biotage microwave initiator at 120 C for 3?6 h with pressure<4 bar. The reaction was cooled and transferred to a flask, and thesolvent was evaporated at reduced pressure. The residue wasdiluted with EtOAc, neutralized with NH4OH, and then washedwith water (2 10 mL). After drying with anhydrous Na2SO4, theorganic solvent was concentrated in a rotary evaporator to <1mL. This residue was placed on top of a silica gel column and elutedwith hexane and EtOAc or with CHCl3 and MeOH. Fractions containingthe product (TLC) were pooled and evaporated to affordpure compounds 3?7, 9?14.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Xiang, Weiguo; Choudhary, Shruti; Hamel, Ernest; Mooberry, Susan L.; Gangjee, Aleem; Bioorganic and Medicinal Chemistry; vol. 26; 9; (2018); p. 2437 – 2451;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem