Related Products of 74137-36-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 74137-36-3, name is 1,3-Dibromo-5-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.
Step 3: Pd(PPh3)4 (600 mg, 0.53 mmol, 0.1 eq.) and Cs2CO3 (3.40 g,10.52 mmol, 2.0 eq.) were added to a stirred solution of N-(5-(4,4,5,5- tetramethyl-1 ,3,2-d ioxaborolan-2-yl)-pyridi n-2-yl)-2-methylpyri midi ne-5-carboxamide (1 .78 g, 5.26 mmol, 1 .0 eq.) and dibromoanisole (1 .40 g, 5.26 mmol, 1.0 eq.) in dioxane (14 ml) at RT under a nitrogen atmosphere. The reaction mixture was heated to 100 ¡ãC for 16 h after which time it was allowed to cool to RT. The reaction mixture was then filtered and the filtrate was concentrated under reduced pressure. The residue was diluted withethyl acetate (100 mL) and washed with water and brine (100 mL each). The organic layer was dried over Na2504 and concentrated under reduced pressure to give crude product. This material was purified by flash chromatography (over silica gel 230-400 mesh) eluting with 2 percent methanol in DCM to afford pure N-[5-(3-bromo-5-methoxyphenyl)pyridin-2-yl]-2-methylpyrimidine-5-carboxamide (1.20 g; 57percent).
The chemical industry reduces the impact on the environment during synthesis 1,3-Dibromo-5-methoxybenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; FROST BIOLOGIC, INC.; SIDDIQUI-JAIN, Adam; WO2015/127284; (2015); A2;,
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