Electric Literature of 134364-69-5,Some common heterocyclic compound, 134364-69-5, name is 2,3-Difluoroanisole, molecular formula is C7H6F2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 1 L four-necked flask purged with nitrogen, 102 gOf 1, 2-difluoro-3-methoxybenzene was dissolved in 300 ml of THF and cooled to -78 C. To this was added 326 ml of a 2.4 M solution of butyllithium in hexane over 1 hour. After 1 hour, a solution of 133 g of trimethyl borate dissolved in 130 ml of THF was added dropwise over 1 hour. After 1 hour, the temperature of the system was brought to -30 C., 160 ml of 36% hydrochloric acid was added and the mixture was stirred for 2 hours. To the system, 500 ml of ethyl acetate and 200 ml of water were added and stirred, and the organic layer was separated. The mixture was further extracted with 200 ml of ethyl acetate and combined with the above organic layer, which was washed with 100 ml of saturated brine. After drying the solution with magnesium sulfate, the solvent was distilled off to obtain 133 g of the desired product as a white solid. Yield 100%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,3-Difluoroanisole, its application will become more common.
Reference:
Patent; DIC CORPORATION; KUSUMOTO, TETSUO; AOKI, YOSHIO; (47 pag.)JP6136589; (2017); B2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem