Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5905-69-1, name is 1-Bromo-4-(difluoromethoxy)benzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Bromo-4-(difluoromethoxy)benzene
Example 178 2-[5-[4-(Difluoromethoxy)phenyl]-2-oxo-1,3-benzoxazol-3(2H)-yl]-N-methyl-N-phenylacetamide To a solution of the compound synthesised in Reference Example 36 (50.0 mg, 122 mumol), 1-bromo-4-(difluoromethoxy)benzene (20.1 muL, 147 mumol) and tetrakistriphenylphosphine palladium (7.08 mg, 6.12 mumol) in 1,4-dioxane (2.0 mL) is added a solution of potassium carbonate (50.8 mg, 367 mumol) in water (0.40 mL), and the mixture is stirred under reflux for 2 hours. After the reaction, the reaction mixture is poured into water at 0C, and extracted with ethyl acetate. The organic layer is washed with a saturated saline solution, and dried over anhydrous sodium sulfate. The drying agent is removed by filtration, and the solvent is evaporated under reduced pressure. The obtained crude product is purified by silica gel chromatography (hexane/ethyl acetate = 3/1) to give 2-[5-[4-(difluoromethoxy)phenyl]-2-oxo-1,3-benzoxazol-3(2H)-yl]-N-methyl-N-phenylacetamide (21.1 mg, 41 %). IR (cm-1): 696, 1111, 1495, 1674, 1774
The synthetic route of 5905-69-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; EP1719761; (2006); A1;,
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