Electric Literature of 54149-17-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 54149-17-6 as follows.
To a solution of m-toluidine (lOg, 9.3mmol) in DMF (lOmL), 1-bromo-2-(2- methoxyethoxy)ethane (0.85g, 4.6mmol) and diisopropylamine (1.2g, 0.93mmol) was added. The mixture was heated to 100C for 4h. The mixture was diluted with ethyl acetate and water, and the layers were separated. The organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was then concentrated. The residue was purified by column chromatography (silica, heptane/ethyl acetate) to afford the desired product (650mg, 66%) as an oil. ?H NMR (300 MHz, CDC13) oe 7.07 (t, J 7.5, 1H), 6.56 (d, J 7.5, 1H), 6.52 – 6.45 (m, 2H), 3.71 (t, J= 5.3, 2H), 3.67 – 3.62 (m, 2H), 3.60 – 3.52 (m, 2H), 3.31 (t, J= 5.3, 2H), 2.28 (s, 3H); ESI MS m/z 210 [M + Hj.
According to the analysis of related databases, 54149-17-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PROMEGA CORPORATION; DUELLMAN, Sarah; ROBERS, Matthew, B.; WALKER, Joel, R.; ZHOU, Wenhui; ZIMPRICH, Chad; (230 pag.)WO2016/210294; (2016); A1;,
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